博士（薬学）

神経精神薬理学

先端薬学研究特論

ストレス性精神疾患の病態解明と新規治療戦略開発に関する研究

研究は、一人で進めるものではありません。教員や学生同士が議論を重ね、互いに学び合いながら、新しい知見を創造していくプロセスです。ストレスと脳機能、精神疾患のメカニズムの解明を通じて、新たな治療法や予防法の創出につながる研究を進めています。このような研究に興味を持ち、新しい発見に挑戦したい意欲のある方を歓迎します。

性差に着目したストレス応答機構と精神疾患の病態解明

【researchmap】

https://researchmap.jp/30454846

【主な著書】

• 1. Kurokawa K, Takahashi H, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M: Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus. Neurochem Int. 査読有 151:105213 2021
• 2. Kurokawa K, Tsuji M, Takahashi H, Miyagawa K, Mochida-Saito A, Takeda H: Leukemia inhibitory factor participates in the formation of stress adaptation via hippocampal myelination in mice. Neuroscience. 446:1-13 2020
• 3. 黒川　和宏、大熊　誠太郎、武田　弘志、辻稔: グルタミン酸ニューロンを介したacamprosateの抗酒作用　星和書店23(8):811-816. 2020
• 4. Ohno R, Miyagishi H, Tsuji M, Saito A, Miyagawa K, Kurokawa K, Takeda H. Yokukansan, a traditional Japanese herbal medicine, enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT2A receptor expression in mice. Journal of Ethnopharmacology. 査読有216, 89-96. 2018
• 5. Saito A, Miyagawa K, Miyagishi H, Kurokawa K et al. ,Possible involvement of monoamine neurons in the emotional abnormality in Kir6.2-deficient mice. Physiology and Behavior. 査読有188, 251-261. 2018
• 6. Mizuno K, Kurokawa K, Ohkuma S Nicotinic acetylcholine receptors regulate type 1 inositol 1,4,5-trisphosphate receptor expression via calmodulin kinase IV activation. J Neurosci Res 93,660-665. 2015
• 7. Kurokawa K, Mizuno K, Ohkuma S: Increase of type 2 ryanodine receptors in mouse nucleus accumbens in the development and expression of morphine-induced place preference. J Pharmacol Sci. 査読有 126(3):285-290. 2014
• 8. Kurokawa K, Mizuno K, Ohkuma S: Sensitization of ethanol-induced place preference as result of up-regulation of type 1 inositol 1,4,5-trisphosphate receptors in mouse nucleus accumbens. J Neurochem. 査読有 131(6):836-847. 2014
• 9. 黒川　和宏、水野晃治、大熊　誠太郎：アルコール依存症の中枢神経機能変化　精神科　24(5): 508-515. 2014
• 10. Kurokawa K, Mizuno K, Ohkuma S: Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence. Alcohol Clin Exp Res査読有37:771-783. 2013
• 11. Kurokawa K, Mizuno K, Ohkuma S: Possible involvement of type 1 inositol 1,4,5-trisphoshate receptors up-regulated by dopamine D1 and D2 receptors in mouse nucleus accumbens neurons in the development of methamphetamine-induced place preference. Neuroscience. 査読有 227:22-29. 2012.
• 12. 黒川　和宏、水野晃治、大熊　誠太郎：ベンゾジアゼピンとそのアゴニスト-睡眠薬の現状と課題-　睡眠医療　6:137-142. 2012.
• 13. Kurokawa K, Mizuno K, Kiyokage E, Shibasaki M, Toida K, Ohkuma S: Dopamine D1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons. J Neurochem. 査読有118:773-783. 2011.
• 14. Kurokawa K, Mizuno K, Shibasaki M, Ohkuma S:Regulation of ryanodine receptors by dopamine D1 receptors during methamphetamine-induced place conditioning. J Neurochem. 査読有 115: 1206-1214. 2010.