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教員情報

宮川 和也
（みやがわ かずや）准教授

医療・生命薬学専攻／生命薬科学専攻
所属キャンパス： 大田原キャンパス

略歴

【職歴】
国際医療福祉大学薬学部助教、講師を経て現職。博士（薬学）。
日本薬理学会学術評議員、日本神経精神薬理学会評議員、日本緩和医療薬学会評議員、日本ストレス学会理事。

学位

博士（薬学）（星薬科大学）

専門分野

神経精神薬理学、行動薬理学、漢方薬理学、エピジェネティクス、ストレス科学

担当科目

先端薬学研究特論

研究指導テーマ

①ストレス適応に関与する脳内機構の解明
②ストレス性精神疾患に対する新規薬物療法の開発
③妊娠期ストレスが子の精神発達に及ぼす影響と治療戦略の構築

自身の研究テーマ

ストレス性精神疾患の病態解明と新規治療戦略の開発

研究業績

【researchmap】
https://researchmap.jp/KZYMYGW


【著書】
  1. 新世紀 薬理学. 京都廣川書店, 2026（分担執筆）
  2. 知識ゼロから始めるAIによる動物行動解析：動画から動物の心と体の変化を客観的に定量する. 羊土社, 2025（分担執筆）
  3. 行動医学テキスト 第2版. 中外医学社, 2023（分担執筆）
  4. 神経・筋・精神/麻酔・鎮痛. 中山書店, 2019（分担執筆）
  5. Facilitating Resilience After PTSD: A Translational Approach. Nova Science Publishers, Inc., 2018（分担執筆）
  6. 行動医学テキスト. 中外医学社, 2015（分担執筆）
  7. ストレス百科事典. 丸善, 2010（共訳）
  8. 臨床緩和医療薬学. 真興交易医書出版部, 2008（分担執筆）
【論文・総説・著書】
  1. Congenital Kir6.2 deficiency, but not acute KATP channel blockade, attenuates apomorphine-induced locomotor activity in mice. Pharmacology, biochemistry, and behavior, 2026
  2. Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes. NATURE MEDICINE, 2026＊
  3. Host control of persistent Epstein-Barr virus infection. Nature, 2026＊
  4. Biallelic c.2709del and c.3020T>G cause DNAH11-related primary ciliary dyskinesia presenting with Kartagener syndrome: Possible novel phenotype of diffuse-twisting wave-like movements of airway epithelial cell populations. Respiratory Investigation, 2025
  5. Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases. Scientific reports, 2025＊
  6. Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution. Nature genetics, 2025＊
  7. Neuronal dysfunction in the amygdala is involved in anxiety-like behaviors accompanying ulcerative colitis. Neuroscience letters, 2025
  8. Activation of Hippocampal ACE2 Prevents the Dysbiosis-induced Depression-like Behavior in Mice by Enhanced Neurogenesis and Neuroprotection via Mas Receptor. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2025
  9. 基礎と臨床から紐解く発達期ストレスの包括的考究 妊娠期のストレス環境と仔の情動性 抑肝散の治療可能性を考究する. ストレス科学, 2025
  10. Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder. Cell genomics, 2025＊
  11. Repeated exposure to antibiotics exhibits anxiety-like behaviors with a reduction in neurogenesis in the ventral hippocampus of dentate gyrus. Neuroscience letters, 2025
  12. Blood DNA virome associates with autoimmune diseases and COVID-19. Nature genetics, 2025＊
  13. Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues. Cell genomics, 2024＊
  14. Anxiolytic effects of Enterococcus faecalis 2001 on a mouse model of colitis. Scientific reports, 2024
  15. Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction. Neurochemistry international, 2024
  16. Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study. Journal of gastroenterology, 2024＊
  17. Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice. Neuroscience letters, 2024
  18. Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study. OTO open, 2024
  19. Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy. Experimental neurology, 2023
  20. Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study. Respiratory investigation, 2023
  21. Possible involvement of inflammasomes on the post-stroke cognitive impairment in a mouse model of embolic cerebral infarct. Physiology & behavior, 2023
  22. Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity. Nature genetics, 2023＊
  23. Real-world effects of once-daily inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) and long-acting muscarinic antagonist (umeclidinium) on lung function tests of asthma patients in Japan. Frontiers in Physiology, 2023
  24. Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry, 2023
  25. Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force. BMC infectious diseases, 2022＊
  26. Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice. Behavioural brain research, 2022
  27. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. Nature communications, 2022
  28. DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature, 2022
  29. Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice. Neuroscience research, 2022
  30. Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice. Brain research, 2022
  31. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice. Journal of psychiatric research, 2022
  32. Effects of smoking cessation using varenicline on the serum concentrations of oxidized high-density lipoprotein: Comparison with high-density lipoprotein cholesterol. PloS one, 2022
  33. Trichostatin A, a histone deacetylase inhibitor, alleviates the emotional abnormality induced by maladaptation to stress in mice. Neuroscience letters, 2022
  34. Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus. Neurochemistry international, 2021
  35. Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior. Neurochemistry international, 2021
  36. Effects of Gadolinium Deposition in the Brain on Motor or Behavioral Function: A Mouse Model. Radiology, 2021
  37. Recent Insights into the Measurement of Carbon Dioxide Concentrations for Clinical Practice in Respiratory Medicine. Sensors (Basel, Switzerland), 2021
  38. Activation of cholinergic system partially rescues olfactory dysfunction-induced learning and memory deficit in mice. Behavioural brain research, 2021
  39. ストレスリジリエンスを制御する分子メカニズムの考究. ストレス科学, 2021
  40. Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice. Brain research, 2020
  41. Leukemia Inhibitory Factor Participates in the Formation of Stress Adaptation via Hippocampal Myelination in Mice. Neuroscience, 2020
  42. Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice. Physiology & behavior, 2020
  43. Characterization of 5-HT1A receptor and transport protein KIF13A expression in the hippocampus of stress-adaptive and -maladaptive mice. Neuroscience letters, 2020
  44. Intermittent hypoxia, energy expenditure, and visceral adipocyte recovery. Respiratory physiology & neurobiology, 2020
  45. Effects of Normoxic Recovery on Intima-Media Thickness of Aorta and Pulmonary Artery Following Intermittent Hypoxia in Mice. Frontiers in physiology, 2020
  46. 【ストレス疾患とエピゲノム】ヒストンアセチル化によるストレスレジリエンスの獲得. ストレス科学, 2019
  47. スコポラミン誘発健忘モデルマウスにおけるドコサヘキサエン酸‒ホスファチジルセリン複合体製剤の学習記憶改善効果. 国際医療福祉大学学会誌 = Journal of the International University of Health and Welfare, 2019
  48. Real-world efficacy and problems of once-daily use of inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) in Japanese patients with asthma. Cogent Medicine, 2019
  49. Involvement of interleukin-31 receptor A in morphine-induced itching and antinociception in mice. European journal of pain (London, England), 2019
  50. Effects of ginger aroma under stress conditions: a biometric perspective. Proceedings of SPIE - The International Society for Optical Engineering, 2019
  51. Possible involvement of monoamine neurons in the emotional abnormality in Kir6.2-deficient mice. Physiology & behavior, 2018
  52. Yokukansan, a traditional Japanese herbal medicine, enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT2A receptor expression in mice. Journal of ethnopharmacology, 2018
  53. 気管支喘息の各種流量データに及ぼすLABA(Vilanterol)を併用した一日一回の吸入ステロイド(Fluticasone Furoate)の効果(Effects of Once-a-day Use of Inhaled Steroid(Fluticasone Furoate) Combined with LABA(Vilanterol) on Various Flow Data in Bronchial Asthma). 日本呼吸器学会誌, 2018
  54. The roles of KATP channels including Kir6.2 in regulation of emotional behaviors and stress responses. 日本薬理学会年会要旨集, 2018
  55. EFFECTS OF ONCE-A-DAY USE OF INHALED STEROID (FLUTICASONE FUROATE) COMBINED WITH LONG-ACTING BETA-2 AGONIST (VILANTEROL) ON VARIOUS FLOW DATA IN BRONCHIAL ASTHMA. RESPIROLOGY, 2017
  56. Inhibitory effect of yokukansan on the decrease in the hippocampal excitatory amino acid transporter EAAT2 in stress-maladaptive mice. Journal of traditional and complementary medicine, 2017
  57. 5-HT7 receptor-mediated fear conditioning and possible involvement of extracellular signal-regulated kinase. Neuroscience letters, 2017
  58. [Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2016
  59. Repeated administration of interleukin-31 attenuates the morphine-induced antinociceptiye tolerance in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016
  60. Repeated administration of interleukin-31 enhances the morphine-induced antinociception in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016
  61. Involvement of interleukin-31 receptor A on the morphine-induced antinociception in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016
  62. Ethanol Withdrawal-Induced Impaired Recognition Is Reversed by Chronic Exposure to Stress and the Acute Administration of Corticosterone in Mice. Biological & pharmaceutical bulletin, 2016
  63. Herbal medicine Goshajinkigan and Rokumigan inhibit Nav1.7 voltage-gated sodium channel current. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015
  64. Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015
  65. Assessment of behavioral phenotype in Kir6.2-deficient mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015
  66. Behavioral pharmacological assessment of animal models of depression and anxiety. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015
  67. Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice. Behavioural brain research, 2015
  68. Repeated administration of IL-31 upregulates IL-31 receptor A (IL-31RA) in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice. Experimental dermatology, 2015
  69. Neuroprotective effect of yokukansan against cytotoxicity induced by corticosterone on mouse hippocampal neurons. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014
  70. Varenicline-assisted smoking cessation decreases oxidative stress and restores endothelial function. HYPERTENSION RESEARCH, 2014
  71. Yokukansan, a traditional Japanese herbal medicine, alleviates the emotional abnormality induced by maladaptation to stress in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014
  72. Acute Effects of Caffeine on Blood Pressure and Heart Rate in Habitual and Non-Habitual Coffee Consumers::A Randomized, Double-Blind, Placebo-Controlled Study. 医療薬学, 2014
  73. Yokukansan, a traditional Japanese herbal medicine, alleviates the anxiety-like behavior induced by prenatal restraint stress in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
  74. Ameliorative effect of yokukansan on the emotional abnormality in stress-maladaptive mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
  75. Effects of corticosterone on the ethanol withdrawal-induced cognitive impairment in ethanol dependent mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
  76. Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation. Journal of pharmacological sciences, 2014
  77. Repeated exposure to stress stimuli during ethanol consumption prolongs withdrawal-induced emotional abnormality in mice. European journal of pharmacology, 2013
  78. PREVALENCE OF DIABETES AND IMPAIRED GLUCOSE TOLERANCE IN PATIENTS WITH SLEEP APNEA SYNDROME. RESPIROLOGY, 2013
  79. The significance of hippocampal histone acetylation as a common factor involved in the development of emotional resistance and adaptation to stress in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013
  80. The influence of chronic stress stimuli on the cognitive function after the ethanol withdrawal in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013
  81. Does smoking cessation with varenicline worsen vascular endothelial function? BMJ OPEN, 2013
  82. [Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2012
  83. [Role of brain 5-HT7 receptors as a functional molecule involved in the development of stress adaptation]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2012
  84. Yokukansan, a traditional Japanese herbal medicine, improve the emotional abnormality induced by maladaptive to stress in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012
  85. Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice. Neuroscience research, 2011
  86. Possible involvement of histone acetylation on the development of emotional resistance to stress stimuli mediated by 5-HT1A receptors in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011
  87. The influence of corticosterone to glial cells proliferation and its characterization. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011
  88. The role of 5-HT7 receptor-ERK signaling on the development of stress adaptation in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011
  89. An update on epigenetic regulation in pathophysiologies of stress-induced psychiatric disorders. Japanese Journal of Neuropsychopharmacology, 2010
  90. Effects of Prenatal and Neonatal Exposure to Bisphenol A on the Development of the Central Nervous System. BIOMOLECULES & THERAPEUTICS, 2010
  91. Possible involvement of the epigenetic regulation on the development of emotional resistance to stress stimuli in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010
  92. Protective effects of the i.c.v.injection of trichostatin A, a histone deacetylase inhibitor, against emotional changes produced by acute restraint stress in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010
  93. Possible involvement of 5-HT7 receptors on extinction learning for contextual fear memory in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010
  94. Pharmacological characterization and mechanisms of the novel antidepressive- and/or anxiolytic-like substances identified from Perillae Herba. Japanese Journal of Neuropsychopharmacology, 2008
  95. Chronic exposure to bisphenol-A causes astrocyte activation in the mouse hippocampus. NEUROSCIENCE RESEARCH, 2008
  96. Dramatic changes in functions of the central dopaminergic system in mice perinatally exposed to bisphenol-A. NEUROSCIENCE RESEARCH, 2008
  97. DNA microarray analysis of gene expression profile in the hippocampus of mice with resistance to stress stimuli. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008
  98. The prenatal stress induces the emotional changes together with the abnormal development of central 5-HT neurons. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008
  99. Possible involvement of brain 5-HT7 receptors in the development of stress adaptation in mice. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008
  100. [Future prospects of drug development for treatment of mood disorders based on studies on stress adaptation]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2008
  101. Behavioral analysis of chronic exposure to diphenylarsinic acid associated with influence on central nervous systems. Japanese Journal of Neuropsychopharmacology, 2007
  102. [Evaluation methods for general and depressive-like behaviors]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2007
  103. Changes in central dopaminergic systems and morphine reward by prenatal and neonatal exposure to bisphenol-A in mice: evidence for the importance of exposure period. ADDICTION BIOLOGY, 2007
  104. Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A. NEUROSCIENCE LETTERS, 2007
  105. Changes in central dopaminergic systems with the expression of Shh or GDNF in mice perinatally exposed to bisphenol-A. Japanese Journal of Neuropsychopharmacology, 2007
  106. Involvement of inflammatory pathway in methamphetamine-induced neurotoxicity. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007
  107. Changes in central dopaminergic neuron development with expression of sonic hedgehog (Shh) or glial cell line-derived neurotrophic factor (GDNF) in mice prenataly and neonatally exposed to bisphenol-A. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007
  108. Effect of acute treatment with neuron/astrocyte conditioned medium activated by the stimulation of 5-HT1A receptor on the anxiolytic behavior. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007
  109. Prenatal and neonatal exposure to low-dose of bisphenol-A enhance the morphine-induced hyperlocomotion and rewarding effect. NEUROSCIENCE LETTERS, 2006
  110. Dynamic changes in dopaminergic neurotransmission induced by a low concentration of bisphenol-A in neurones and astrocytes. JOURNAL OF NEUROENDOCRINOLOGY, 2006
  111. The role of glia cells on the dopaminergic neurobehavioral toxicity induced by exposure to bisphenol-A. NEUROSCIENCE RESEARCH, 2006
  112. Functional role of the glial cells in the induction of stress. NEUROSCIENCE RESEARCH, 2006
  113. Exposure to bisphenol-A affects the rewarding system in mice. Japanese Journal of Neuropsychopharmacology, 2005
  114. The functional change in the 5-HT1A receptor induced by stress and the role of the 5-HT1A receptor in neuroprotection. Japanese Journal of Neuropsychopharmacology, 2005
  115. Prenatal and neonatal exposure to bisphenol-A affects the morphine-induced rewarding effect and hyperlocomotion in mice. NEUROSCIENCE LETTERS, 2004

＊ Japan COVID-19 Task Forceの一員として参加

【主な学会賞】
  1. 国際医療福祉大学学会 第9回国際医療福祉大学学会学術大会優秀発表賞 2019年
    胎生期ストレスが惹起する脳内ヒストン修飾変化の網羅的解析
  2. 日本ストレス学会 日本ストレス学会奨励賞（高田賞）2018年
    胎生期ストレスが惹起する不安感受性の亢進と抑肝散の治療効果
  3. 国際医療福祉大学学会 第8回国際医療福祉大学学会学術大会優秀発表賞 2018年
    胎生期ストレスが惹起する後天的ストレス脆弱性のエピジェネティクス制御メカニズム
  4. 日本薬学会 生体機能と創薬シンポジウム2008 優秀ポスター賞 2008年
    胎生期ストレス刺激による中枢5-HT神経の発達異常と情動変化
【主な外部資金獲得】
  1. 科学研究費 基盤研究（C）（研究代表者）「低酸素誘導因子を基軸としたストレス適応能への妊娠期低酸素曝露の影響と抑肝散の応用」（2025年度 - 2027年度）
  2. 科学研究費 基盤研究（C）（研究代表者）「妊娠期の低酸素状態が子の情動的ストレス応答に及ぼす影響と抑肝散の治療効果」（2022年度 - 2024年度）
  3. 科学研究費 基盤研究（C）（研究代表者）「妊娠期のストレス曝露が誘発する子の情動障害に対する抑肝散の治療メカニズムの解明」（2019年度 - 2021年度）
  4. 科学研究費 若手研究（B）（研究代表者）「妊娠期のストレス曝露が誘発する子の情動障害に対する抑肝散の応用」（2016年度 - 2018年度）
【主な外部資金獲得】
  1. 学研究費　基盤研究（C）（研究代表者）「低酸素誘導因子を基軸としたストレス適応能への妊娠期低酸素曝露の影響と抑肝散の応用」（2025年度 - 2027年度）
  2. 科学研究費　基盤研究（C）（研究代表者）「妊娠期の低酸素状態が子の情動的ストレス応答に及ぼす影響と抑肝散の治療効果」（2022年度 - 2024年度）
  3. 科学研究費　基盤研究（C）（研究代表者）「妊娠期のストレス曝露が誘発する子の情動障害に対する抑肝散の治療メカニズムの解明」（2019年度 - 2021年度）
  4. 科学研究費　若手研究（B）（研究代表者）「妊娠期のストレス曝露が誘発する子の情動障害に対する抑肝散の応用」（2016年度 - 2018年度）

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